Research Article
Efficacy of Platelet-Rich Plasma in Retarding Intervertebral Disc Degeneration: A Meta-Analysis of Animal Studies
Table 3
Subgroup analysis of the disc height based on animal species, study design, disc degeneration model, follow-up period, and disc height measurement.
| | Subgroup analysis index | Number of studies | SMD | 95% CI | value | |
| | Animal species | | | | | | | Rabbit | 5 | 3.14 | 2.19, 4.08 | 0.000 | 62.8% | | Pig | 1 | 1.21 | , 2.45 | 0.058 | NA | | Rat | 1 | 1.83 | 0.44, 3.22 | 0.010 | NA | | Study design | | | | | | | N-RCT | 3 | 2.50 | 0.91, 4.09 | 0.002 | 73.5% | | RCT | 4 | 2.82 | 1.75, 3.89 | 0.000 | 66.6% | | Disc degeneration model | | | | | | | Nucleus pulposus aspiration | 1 | 4.17 | 2.46, 5.89 | 0.000 | NA | | Chymopapain induction | 1 | 1.21 | , 2.45 | 0.058 | NA | | Needle puncture | 5 | 2.68 | 1.86, 3.51 | 0.000 | 55.7% | | Follow-up period | | | | | | | 2 weeks | 1 | 6.01 | 3.58, 8.44 | 0.000 | NA | | 4 weeks | 1 | 1.83 | 0.44, 3.22 | 0.010 | NA | | 6 weeks | 1 | 2.67 | 1.55, 3.80 | 0.000 | NA | | 8 weeks | 4 | 2.43 | 1.49, 3.37 | 0.000 | 60.5% | | Disc height measurement | | | | | | | Absolute disc height | 2 | 2.95 | 0.66, 5.23 | 0.012 | 67.2% | | DHI% | 5 | 2.59 | 1.65, 3.53 | 0.000 | 64.3% |
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RCT: randomized controlled trial; N-RCT: nonrandomized controlled trial. SMD: standardized mean difference; 95% CI: 95% confidence interval. DHI: disc height index.
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