Basal and Activated Calcium Sensitization Mediated by RhoA/Rho Kinase Pathway in Rats with Genetic and Salt Hypertension

Figure 1

The scheme describing pharmacological interventions used in Experiments –3. Activated calcium sensitization was estimated from dose response to fasudil followed by the administration of a single dose of nifedipine in Experiment , whereas voltage-dependent calcium entry was estimated from dose response to nifedipine which was followed by the administration of a single dose of fasudil in Experiment . Basal calcium sensitization was measured as a fasudil-dependent difference in BP elevation induced by dose-dependent administration of calcium channel opener BAY K8644. The blockade of RAS and SNS preceded dose response to BAY K8644 measured prior to and after fasudil infusion in Experiment .