Collagen Sponge Functionalized with Chimeric Anti-BMP-2 Monoclonal Antibody Mediates Repair of Critical-Size Mandibular Continuity Defects in a Nonhuman Primate Model

Figure 3

Quantitative analysis of bone density within axial images of CBCTs taken presurgically and at 6 (a) and 12 (b) weeks postsurgically. Bone density was measured within axial sections of CBCT images obtained from superior, middle, and inferior regions, according to the landmarks illustrated in Figure 2. The mean density of experimental mandibular area at preoperative time point is presented for comparison. Significantly higher bone density was observed within defects treated with chimeric anti-BMP-2 mAb compared to isotype-matched control mAb (, ).

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