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BioMed Research International
Volume 2017, Article ID 8102589, 6 pages
Review Article

Exclusive Enteral Nutrition Induces Remission in Pediatric Crohn’s Disease via Modulation of the Gut Microbiota

1Department of Central Laboratories and Gastroenterology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao 266071, China
2Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao 266071, China
3Department of Emergency Surgery, The Fifth People’s Hospital of Jinan, Jinan 250022, China

Correspondence should be addressed to Quanjiang Dong; ten.haey@bcwyfdq

Received 10 June 2017; Revised 22 August 2017; Accepted 12 September 2017; Published 16 October 2017

Academic Editor: Dimitrios P. Bogdanos

Copyright © 2017 Dawei Gong et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Exclusive enteral nutrition (EEN) has been proven to be effective and safe in treating pediatric Crohn’s disease (CD). EEN induces pediatric CD remission possibly through three pathways: (1) direct anti-inflammatory effects, (2) improved epithelial barrier function, and (3) modulation of the gut microbiota. Recent studies have demonstrated that modulation of the gut microbiota plays a major role in EEN-induced remission. Variations of microbial components, which directly influence the diversity and metabolic functions of the gut microbiota, are closely associated with the immunological conditions of the gut and the susceptibility to diseases. The reduction of proinflammatory microbial components and harmful microbial metabolites after EEN treatment greatly decreases the inflammatory injuries of the gut.