Review of Natural Product-Derived Compounds as Potent Antiglioblastoma Drugs

Table 3

Antiangiogenesis effect of natural products.

Family names	Medical plants	Compounds/extracts	Dose/duration	Target molecules and additional efficacy	Cell lines	References
Araliaceae	Panax ginseng	Ginsenoside Rg3	0–180 μg/ml; for 72 h (in vitro); 10 mg/kg/day; for 8 days (in vivo)	↓VEGF, Bcl-2 (HUVEC mRNA), VEGFA, MVD; Inhibit HUVEC proliferation, less increase rCBV	Rat C6 glioma cells	[68]
Zingiberaceae	Curcuma amada	Supercritical CO2 extract	0–100 μg/ml; for 72 h; 0–20 μg/ml; for 24 h	↓VEGF mRNA, VEGF	U87MG	[79]
Vitaceae	Vitis vinifera	Red grape skin polyphenolic extract	0–25 μg/ml; for 24 h	↓tube network formation, VEGF, S1P, ERK, p38/MAPK phosphorylation, S1P-induced PAF synthesis	U87MG	[80]
Cannabaceae	Cannabis sativa	Δ9-Tetrahydrocannabinol, cannabidiol	7.5 mg/kg/day; for 22 days	↓tumor vascularization (CD31 immunostaining)	U87MG	[28]