Review of Natural Product-Derived Compounds as Potent Antiglioblastoma Drugs

Table 5

miRNA regulation of natural products.

Family names	Medical plants	Compounds/extracts	Dose/duration	Target molecules and additional efficacy	Cell lines	References
Oleaceae	Olea europaea	Oleuropein	1 mg/ml, 2 mg/ml for 24 h	↑miR-153, miR-145, miR-137	T98G,; U-138MG,; U-87MG	[51]
Moraceae	Ficus carica	Protocatechuic acid	0.25 mg/ml for 24 h	↑let-7d, VEGF; ↓neovascularization	T98G,; U-138 MG,; U-87 MG	[52]
Boraginaceae	Lithospermum erythrorhizon	Shikonin	2 mg/kg for 24 h	↑miR-143, BAG3	GSC	[87]
Berberidaceae	Berberis amurensis	Berbamine	5 mM for 24 h	↑caspase-3, PARP, miR-4284, JNK1, JNK 2, SAPK, phosphorylated c- Jun, total c-Fos; apoptosis, JNK-c-Jun/AP-1 signaling pathway	PBT003, PBT008, PBT022,; PBT030	[56]
Oleaceae	Olea europaea	Oleuropein	1 mg/ml for 24 h, 48 h	miR-181b, miR-153, miR-145, miR-137, ↑let-7d	T98G	[88]
Zingiberaceae	Curcuma longa	Curcumin (diferuloylmethane)	20 μM for 72 h	↑miR-146a; ↓NF-κB	U-87 MG	[89]