New Frontiers in Genetics, Gut Microbiota, and Immunity: A Rosetta Stone for the Pathogenesis of Inflammatory Bowel Disease

Figure 1

Roles for genetics and epigenetics in IBD pathogenesis. Epigenetics, acting as the mediators of genetic and environmental factors, along with genetic, external environmental factors and internal gut microbiota, participate in motivating the host immune system. The consequence of the following immune response is whether insults tolerance or chronic inflammation initiation and development occur.