Ameliorative Effect of Cactus (Opuntia ficus indica) Extract on Lithium-Induced Nephrocardiotoxicity: A Biochemical and Histopathological Study

Figure 4

Sections of heart tissue obtained from rats of control groups and treated with CCE in lithium carbonate-induced rats (H and E, ×400). Heart tissue of the control rats showed normal myocardial fibers and muscle bundles with normal architecture (a). Heart tissue of lithium-treated rats showed separation of myocardial fibers with inflammatory mononuclear collections, edema, and myocardial necrosis (b). Myocardial section of CCE-treated rats showed slightly separated myocardial fibers with small focus of inflammatory mononuclear collections with the absence of necrotic damage (d). CCE alone-treated rats showed normal myocardial fibers with no pathological changes (c).

(a)

(b)

(c)

(d)