BioMed Research International / 2017 / Article / Tab 1

Research Article

Role of P-Glycoprotein Inhibitors in the Bioavailability Enhancement of Solid Dispersion of Darunavir

Table 1

Saturation solubility and % drug content of eighteen batches of solid dispersion (as predicted by Simple Custom Design) using Soluplus and Kolliphor TPGS. Data presented as mean ± SD, for each formulation .

Exp.Formulation codePolymerPolymer : drugMethodSaturation solubility (mg/ml) mean ± SD% drug content

1SD1P10.5 : 1SE
2SD2P12 : 1S.D
3SD3P20.5 : 1MM
4SD4P20.5 : 1SE
5SD5P10.5 : 1S.D
6SD6P21.25 : 1SE
7SD7P22 : 1S.D
8SD8P12 : 1SE
9SD9P12 : 1MM
10SD10P22 : 1SE
11SD11P21.25 : 1MM
12SD12P11.25 : 1SE
13SD13P21.25 : 1S.D
14SD14P11.25 : 1MM
15SD15P20.5 : 1S.D
16SD16P22 : 1MM
17SD17P11.25 : 1S.D
18SD18P10.5 : 1MM

P1 = Soluplus, P2 = Kolliphor TPGS, MM = melt method, SE = solvent evaporation, and SD = spray drying.

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