Research Article
Triclocarban and Triclosan Inhibit Human Aromatase via Different Mechanisms
Figure 4
Kinetics of CYP19A1 and effects of triclocarban and triclosan on CYP19A1 activity in JEG-3 microsomes. (a) Kinetics of CYP19A1 in the presence of a range of concentrations of testosterone. (b) Single concentration (100 μM) of triclocarban and triclosan was used to inhibit CYP19A1. Mean ± SEM, . ∗∗∗ indicates a significant difference when compared to control at .
(a) Kinetics |
(b) % inhibition at 100 × 10−6 M |