Triclocarban and Triclosan Inhibit Human Aromatase via Different Mechanisms

Table 1

The enzyme kinetics parameters and the half maximal inhibitory concentration (IC₅₀) and modes of action of triclocarban and triclosan.

	Triclocarban	Triclosan
IC50 (×10^−6 M)	15.807 ± 0.110	6.265 ± 0.102
Mode versus testosterone	Noncompetitive	Competitive
Free energy: androstenedione	−9.13	−9.13
Free energy: chemical	−6.899	−7.397
Binding	Not in the steroid site	In the steroid site

Mean ± SEM, .