Research Article

Upregulation of Mitf by Phenolic Compounds-Rich Cymbopogon schoenanthus Treatment Promotes Melanogenesis in B16 Melanoma Cells and Human Epidermal Melanocytes

Table 1

Top ten (10) genes differentially upregulated in B16 cells following treatment with Cymbopogon schoenanthus (CYM) ethanol extract (control versus CYM).

Gene symbolGene nameMolecular functionBiological FunctionFold change

Tmsb10Thymosin, beta 10Actin monomer bindingActin cytoskeleton organization21.6

Rplp0Ribosomal protein, large, P0Poly(A) RNA bindingCellular response to interleukin-4/ribosome biogenesis20.8

Tyrp1Tyrosinase-related protein 1Copper ion binding; oxidoreductase activity; protein bindingMelanin metabolic process; melanocyte differentiation; melanosome organization; pigmentation’ positive regulation of melanin biosynthetic process20.2

Rps3Ribosomal protein S3DNA binding; HSP70 protein binding; HSP90 protein binding; kinase/lyase binding; microtubule binding; NF-kB binding; SUMO binding; nucleic acid binding;Negative regulation of translation; positive regulation of gene expression; positive regulation of JUN kinase activity; positive regulation f microtubule polymerization; response to oxidative stress; response to TNF agonist; spindle assembly;19.8

PpiaPredicted pseudogene 9234/peptidylprolyl isomerase ACyclosporine A binding; isomerase activity; poly(A) RNA bindingNeuron differentiation (part of oligodendrocyte); lipid particle organization; protein folding;19.8

Rplp2Ribosomal protein, large P2Structural constituent of ribosomes;Translational elongation19.4

VimVimentinDouble-strand RNA binding; glycoprotein binding; kinase binding; protein binding; protein kinase bindingAstrocyte development; Bergmann glial cell differentiation; intermediate filament organization; negative regulation f neuron projection development; positive regulation of glial cell proliferation; regulation of axonogenesis; regulation of Schwann cell migration; SMAD protein signal transduction;19.0

Chchd2/Gm13202Coiled-coil-helix-coiled-coil-helix domain containing 2/predicted gene 13202Sequence-specific DNA binding; transcription factor binding;Positive regulation of transcription from RNA polymerase II promoter; regulation of cellular response to hypoxia; transcription, DNA-templated19.0

DctDopachrome tautomeraseDopachrome isomerase activity; metal ion binding; oxidoreductase activityCell development; developmental pigmentation; melanin biosynthetic process; pigmentation; positive regulation of neuroblast proliferation; ventricular zone neuroblast division; melanin biosynthetic process from tyrosine; metabolic process19.0

ActbActin, betaATP binding; identical protein binding; kinesin binding;Axonogenesis; cellular response to electrical stimulus (part of oligodendrocyte, myelin sheath)18.8