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BioMed Research International
Volume 2017, Article ID 8412508, 13 pages
Review Article

Natural Products as Adjunctive Treatment for Pancreatic Cancer: Recent Trends and Advancements

1Department of Oncology, Shanghai 9th People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ, USA
3Department of Cardiothoracic Surgery, Weihai Municipal Hospital, Weihai, Shandong, China
4Department of Pathology, Weihai Municipal Hospital, Weihai, Shandong, China
5Department of Internal Medicine, University of Missouri Hospital and Clinics, Columbia, MO, USA
6Allan H. Conney Laboratory for Anticancer Research, School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou, China

Correspondence should be addressed to Qingxi Yue; and Xi Zheng; ude.sregtur.ycamrahp@gnehzix

Received 3 August 2016; Revised 9 December 2016; Accepted 27 December 2016; Published 23 January 2017

Academic Editor: Li Jiao

Copyright © 2017 Qingxi Yue et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Pancreatic cancer is a type of common malignant tumors with high occurrence in the world. Most patients presented in clinic had pancreatic cancer at advanced stages. Furthermore, chemotherapy or radiotherapy had very limited success in treating pancreatic cancer. Complementary and alternative medicines, such as natural products/herbal medicines, represent exciting adjunctive therapies. In this review, we summarize the recent advances of using natural products/herbal medicines, such as Chinese herbal medicine, in combination with conventional chemotherapeutic agents to treat pancreatic cancer in preclinical and clinical trials.