Laryngeal Rosai-Dorfman Disease (Sinus Histiocytosis with Massive Lymphadenopathy): A Retrospective Study of 5 Cases

Figure 3

The course of treatment and relevant efficacy for a classical case of RDD with laryngeal involvement. (a) The pretreatment laryngoscopy revealed a normal left vocal cord but involvement in the right vocal cord and subglottic area. The movement of the right vocal cord was restricted. (b) Review after 1 month of prednisone 30 mg × 2 W + cladribine 50 mg × 1 W showed no apparent changes in the laryngeal lesions. (c) A review of the laryngoscopy images generated 6 months after the endoscopic operation revealed that the subglottic tumors had almost disappeared and that the subglottic trachea displayed no apparent abnormalities. (d) A review 3 years after the first endoscopic surgery revealed progression of the lesions in the inferior and anterior regions of the glottis. (e) A review 3 years after the endoscopic surgery revealed that the subglottic lesions were partially obstructing the airway. Black stars indicate the lesions in the anterior region of the glottis, whereas white stars indicate the newly developed subglottic lesions.

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