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BioMed Research International
Volume 2017, Article ID 8523649, 7 pages
Review Article

Advances in the Diagnosis and Treatment of Acute Kidney Injury in Cirrhosis Patients

1Department of Gastroenterology and Hepatology, West China Hospital, Sichuan University, Chengdu, China
2Department of Gastroenterology and Hepatology, Sichuan Provincial People’s Hospital, Chengdu, China

Correspondence should be addressed to Hu Zhang; nc.ude.ucs@uhgnahz

Received 3 November 2016; Accepted 22 January 2017; Published 10 May 2017

Academic Editor: Shanhong Tang

Copyright © 2017 Lei Lei et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Liver cirrhosis is a common progressive and chronic clinical liver disease. Due to the strong compensation ability of the liver, no obvious symptoms develop in the early stage. However, multiple systems are involved in decompensation of the liver. Acute kidney injury (AKI) is one of the most serious complications, characterized by a sharp drop in the glomerular filtration rate (GFR); a rapid increase in Scr and BUN, as well as sodium and water storage; and a disturbance of acid-base balance. The mortality rate is high, and the prognosis is very poor. Thus, it is important to make a definite diagnosis and initiate treatment in the early stage to decrease mortality and improve the prognosis. Although diagnosing liver cirrhosis with serum creatinine has many shortcomings, a dynamic change in this marker is still the main diagnostic criterion for AKI. Identifying new markers of kidney injury with clinical value has also become an increasing focus of research. In this text, we review recent changes regarding categorization of AKI diagnostic criteria as well as new markers of AKI and treatments for cirrhosis-related AKI.