Advances in the Diagnosis and Treatment of Acute Kidney Injury in Cirrhosis Patients

Table 2

International Club of Ascites (ICA-AKI) 2015 definition for the diagnosis and management of AKI in patients with cirrhosis.

Subject	Definition
Baseline Scr	A Scr value obtained in the previous 3 months, when available, can be used as the baseline Scr. In patients with more than one value within the previous 3 months, the value closest to the admission time to the hospital should be used. In patients without a previous Scr value, the Scr upon admission should be used as the baseline value
Definition of AKI	Increase in Scr ≥ 0.3 mg/dl (≥26.5 µmol/L) within 48 h or a percentage increase in Scr ≥ 50% from baseline that is known or presumed to have occurred within the previous 7 days
Staging of AKI	Stage 1. Increase in Scr ≥ 0.3 mg/dl (26.5 µmol/L) or an increase in Scr ≥ 1.5-fold to 2-fold from baseline; Stage 2. Increase in Scr > 2-fold to 3-fold from baseline; Stage 3. Increase in Scr > 3-fold from baseline or Scr ≥ 4.0 mg/dl (353.6 µmol/L) with an acute increase ≥0.3 mg/dl (26.5 µmol/L) or initiation of renal replacement therapy
Progression of AKI	Progression. Progression of AKI to a higher stage or need for RRT; Regression. Regression of AKI to a lower stage
Response to treatment	No Response. No regression of AKI; Partial Response. Regression of AKI stage with a reduction of Scr to ≥0.3 mg/dl (26.5 µmol/L) above the baseline value; Full Response. Return of Scr to a value within 0.3 mg/dl (26.5 µmol/L) of the baseline value