Serum Proteome Alterations in Patients with Cognitive Impairment after Traumatic Brain Injury Revealed by iTRAQ-Based Quantitative Proteomics

Table 3

KEGG pathways associated with the differentially expressed proteins (DEPs) identified by iTRAQ analysis.

Number	Pathway ID	Pathway	DEPs with pathway annotation	Mapped DEPs	value
1	ko05322	Systemic lupus erythematosus	3	P0C0L5, P12814, Q96KK5	0.001338
2	ko05133	Pertussis	3	P05155, P0C0L5, P62158	0.003080
3	ko04510	Focal adhesion	4	P02751, P12814, P35443, Q9Y490	0.010071
4	ko05144	Malaria	2	P35443, P68871	0.011312
5	ko05010	Alzheimer's disease	3	P04406, P06858, P62158	0.015594
6	ko05130	Pathogenic Escherichia coli infection	2	P68366, Q9H4B7	0.021948
7	ko04260	Cardiac muscle contraction	2	P06753, P68032	0.026523
8	ko04261	Adrenergic signaling in cardiomyocytes	3	P06753, P62158, P68032	0.027736
9	ko04970	Salivary secretion	2	P49913, P62158	0.032064
10	ko04610	Complement and coagulation cascades	2	P05155, P0C0L5	0.032890
11	ko04512	ECM-receptor interaction	2	P02751, P35443	0.037802
12	ko05410	Hypertrophic cardiomyopathy (HCM)	2	P06753, P68032	0.038242
13	ko05414	Dilated cardiomyopathy (DCM)	2	P06753, P68032	0.039573
14	ko04145	Phagosome	3	P35443, P68366, Q9H4B7	0.041505
15	ko05146	Amoebiasis	2	P02751, P12814	0.043672
16	ko04540	Gap junction	2	P68366, Q9H4B7	0.045073