Research Article

The Phytoestrogen Genistein Produces Similar Effects as 17β-Estradiol on Anxiety-Like Behavior in Rats at 12 Weeks after Ovariectomy

Figure 2

Involvement of the ERβ on the anxiolytic-like effect of 17β-estradiol or genistein in elevated plus maze. (a) Time spent on the open arms. (b) Number of entries into the open arms. (c) Total arm entries (open + closed). (d) Percentage of entries into the open arms. versus Vehicle, T, 17β-E2-T, and Genistein-T. One-way ANOVA followed by Student-Newman-Keuls post hoc test. T, 5-mg/kg tamoxifen; 17β-E2, 0.09-mg/kg 17β-estradiol; Genistein 0.09 mg/kg.