The Bioinformatic Analysis of the Dysregulated Genes and MicroRNAs in Entorhinal Cortex, Hippocampus, and Blood for Alzheimer’s Disease

Table 1

KEGG pathway enrichment for the overlapping genes between target genes of the four microRNAs (has-let-7d, has-miR-144, has-miR-374a, and has-miR-106b) and the DEGs in EC and HIP regions.

Term	Count	value	Genes
MAPK signaling pathway	13	0.0062	RPS6KA5, AKT1, MAP4K4, MAP3K5, PLA2G4A, DUSP2, FGF9, TGFBR1, MAP2K4, MKNK2, PPP3R1, FGF12, DUSP6
Endocytosis	10	0.010	IGF1R, ADRB3, FLT1, TGFBR1, PSD3, VPS4B, DNAJC6, PSD2, ARAP2, LDLRAP1
Axon guidance	7	0.042	EPHA5, SEMA6A, PLXNA1, PPP3R1, SEMA4C, L1CAM, SRGAP1
Insulin signaling pathway	6	0.0076	AKT1, L1CAM, IGF1R, IRS2, SOCS7, RHOQ
Focal adhesion	4	0.021	VCAM1, L1CAM, ITGA4, CERCAM