Expression, Mutation, and Amplification Status of EGFR and Its Correlation with Five miRNAs in Salivary Gland Tumours

Table 5

Association between tumour characteristics and overall survival. Univariate analysis (Cox proportional hazards regression model) is shown in the left panels and multivariate analysis (Cox regression with stepwise backwards selection) in the right panels. Statistically significant values in the univariate analysis and in the last step of the multivariate analysis are shown in bold. HR, hazard ratio; CI, confidence interval.

Characteristics ( = available data)	Univariate model			Multivariate model
	HR	95% CI	value	HR	95% CI	value
Male	0.57	0.28–1.16	0.12
Age > 60 years	2.88	1.29–6.43	0.01	2.22	0.97–5.08	0.05
Tumour size ≥ 2 cm	1.56	0.67–3.63	0.36
Lymph node infiltration	1.84	1.25–2.73	0.001
Radiotherapy	3.60	1.48–8.76	0.005	2.91	1.17–7.25	0.02
Poor clinical prognosis	2.01	1.00–4.01	0.049
ICH EGFR	1.00	0.99–1.00	0.10
CNV EGFR	0.93	0.80–1.08	0.35
miR-99b	1.05	0.80–1.38	0.71
miR-133b	0.93	0.82–1.06	0.27
miR-140	1.04	0.87–1.24	0.70
miR-140-3p	1.01	0.84–1.22	0.89
let-7a	1.01	0.76–1.34	0.93