Enhancement of Angiogenesis by Ultrasound-Targeted Microbubble Destruction Combined with Nuclear Localization Signaling Peptides in Canine Myocardial Infarction

Figure 1

Schematic diagram of the myocardial infarction (MI) model using coronary artery embolism. (a) The puncture was performed at the obvious pulse location on the right femoral artery. (b) The artery sheath was inserted after puncture. (c) After the angiographic catheter reached the opening of the left coronary artery, the microguide wire and catheter could access the left anterior descending coronary artery. (d) The left coronary artery branches were clearly displayed before the MI modeling by coronary angiography. D1 = the first diagonal branch; D2 = the second diagonal branch; and D3 = the third diagonal branch. (e) After embolism of the coronary artery, the second diagonal branch distal of the left anterior descending artery was blocked. The second coronary angiography confirmed ischemia in the embolism area.

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