The Anti-Inflammatory Activity of Toonaciliatin K against Adjuvant Arthritis

Figure 2

The signaling pathways involved in the anti-inflammatory activities of toonaciliatin K in vitro. The RAW264.7 cells were induced with toonaciliatin K exposure (7, 14, or 28 μM) combined with LPS (10 ng/mL) for 12 h. The dexamethasone (Dex, 0.5 μg/mL) was conducted as positive. The control group received no LPS and toonaciliatin K. (a) The NF-κB signaling pathway activity and its quantification. (b) The MAPK signaling pathway activity and its quantification. (c) The AKT signaling pathway activity and its quantification. Statistical differences in different concentrations were considered significant at the levels of , , or . The statistical differences among LPS group and control group were considered significant at the levels of .

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