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BioMed Research International
Volume 2017 (2017), Article ID 9489825, 10 pages
Clinical Study

Histologic and Histomorphometric Comparison between Sintered Nanohydroxyapatite and Anorganic Bovine Xenograft in Maxillary Sinus Grafting: A Split-Mouth Randomized Controlled Clinical Trial

1Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy
2Private Practice, Cassano allo Ionio, Italy
3Private Practice, Verona, Italy
4Private Practice, Firenze, Italy
5Department of Medical, Oral and Biotechnological Sciences, University of Chieti-Pescara, Chieti, Italy

Correspondence should be addressed to Claudio Stacchi

Received 13 January 2017; Accepted 25 May 2017; Published 6 August 2017

Academic Editor: Hassan Maghaireh

Copyright © 2017 Claudio Stacchi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The presence of vital bone after maxillary sinus augmentation is crucial to enhance the quality of bone-implant interface, ensuring predictable long-term results. The aims of this RCT with split-mouth design were the histologic and histomorphometric comparison of two different biomaterials in sinus elevation after 6 months of healing and the evaluation of the clinical outcomes of implants inserted in the augmented areas after 12 months of prosthetic loading. Twenty-eight patients (10 females, 18 males) were treated with bilateral sinus floor elevation with lateral approach. Pure sintered nanohydroxyapatite (NHA) and anorganic bovine bone (ABB) were used as test and active control, respectively. After six months, 52 bone biopsies were harvested from 26 patients, and 107 implants were inserted in the augmented areas. Histomorphometry showed that, in the two groups, vital bone percentages were % (NHA) and % (ABB) (), marrow spaces percentages were % (NHA) and % (ABB) (), and residual graft percentages were % (NHA) and % (ABB) (). After 6 months of healing, no statistically significant difference was present in histomorphometric outcomes between NHA and ABB groups. Implant survival rate in NHA group after 12 months of loading was 96.4%, showing no statistically significant differences with ABB group.