SOX6 Downregulation Induces γ-Globin in Human β-Thalassemia Major Erythroid Cells

Table 6

Information of each donor or patient (SOX6).

	γ-Globin; (fold increase)	SOX6; (percentage knockdown)	HbF; (baseline)	Genotype
Donor 1	3.85	48.7%	1.1%	/
Donor 2	4.07	55.2%	0.8%	/
Donor 3	2.08	35.1%	2.3%	/
Patient 1	2.63	29.9%	31.3%	β^0/β^+
Patient 2	2.08	36.0%	45.7%	β^0/β^+
Patient 3	1.16	41.7%	65.6%	β^0/β^+

Donor: health donor; Patient: β-thalassemia major patient; γ-globin (fold increase): fold increase in γ-globin gene expression in shRNA group compared to control group; SOX6 (percentage knockdown): percentage knockdown of SOX6; HbF (baseline): inherent baseline HbF percentage of each donor and patient; genotype: genotype of each β-thalassemia major patient.