Association between NLPR1, NLPR3, and P2X7R Gene Polymorphisms with Partial Seizures
Table 3
Genotypic and allelic distribution of the NLRP1 gene between male patients and controls .
SNP
Genotype/allele
Case (%)
Control (%)
value
OR (95% CI)
value
rs8079034
CC
63 (70.8)
78 (78.8)
0.432 (1.678)
1.00
Referent
CT
23 (25.8)
18 (18.2)
0.632 (0.314–1.274)
0.199
TT
3 (3.4)
3 (3.0)
0.808 (0.158–4.140)
0.798
CT + TT
26 (29.2)
21 (21.2)
0.206 (1.600)
0.652 (0.336–1.267)
0.207
C
149 (83.7)
174 (87.9)
0.246 (1.347)
1.00
Referent
T
29 (16.3)
24 (12.1)
0.709 (0.395–1.270)
0.247
rs878329
GG
69 (77.5)
57 (57.6)
0.015 (8.466)
1.00
Referent
GC
17 (19.1)
35 (35.4)
2.492 (1.266–4.906)
0.008
CC
3 (3.4)
7 (7.0)
2.825 (0.698–11.423)
0.145
GC + CC
20 (22.5)
42 (42.4)
0.004 (8.441)
2.542 (1.344–4.810)
0.004
G
155 (87.1)
149 (75.3)
0.004 (8.467)
1.00
Referent
C
23 (12.9)
49 (24.7)
2.216 (1.286–3.818)
0.004
CI, confidence interval; OR, odds ratio. value for genotype and allele frequencies in cases and controls using 2-sided test. values adjusted by age and gender using logistic regression. .
