Tempol, a Superoxide Dismutase Mimetic Agent, Inhibits Superoxide Anion-Induced Inflammatory Pain in Mice

Figure 8

Tempol inhibits carrageenan and complete Freund’s adjuvant- (CFA-) induced hyperalgesia. Mice were treated with tempol (100 mg/kg) or vehicle 40 min before carrageenan or CFA intraplantar injection. Nociceptive thresholds to mechanical and thermal stimuli were measured 1–5 h after carrageenan injection (panels (a) and (b), resp.) and 1–7 days after CFA injection (panels (c) and (d), resp.). Results are expressed as means ± SEM ( per group per experiment, representative of two separate experiments) [ versus saline; versus carrageenan + vehicle for panels (a)-(b) and versus CFA + vehicle for panels (c)-(d) (ANOVA followed by Tukey’s -test)].

(a)

(b)

(c)

(d)