Relationship between HLA-DQ Gene Polymorphism and Hepatitis B Virus Infection

Table 2

Main results of the meta-analysis of the association between HLA-DQ (rs2856718 and rs7453920) polymorphism and the risk of HBV infection.

Polymorphism	Allele model		Homozygous model		Heterozygous model		Dominant model		Recessive mode
rs2856718	G versus A		GG versus AA		AG versus AA		(AG + GG) versus AA		GG versus (AG + AA)
	OR (95% CI)		OR (95% CI)		OR (95% CI)		OR (95% CI)		OR (95% CI)
HBV infection versus control
Overall	0.65 (0.59–0.73)	<0.001	0.44 (0.36–0.55)	<0.001	0.66 (0.62–0.72)	0.038	0.58 (0.52–0.65)	0.008	0.58 (0.47–0.71)	<0.001
Asian	0.66 (0.58–0.75)	<0.001	0.45 (0.35–0.58)	<0.001	0.70 (0.64–0.76)	0.449	0.61 (0.54–0.69)	0.016	0.56 (0.44–0.71)	<0.001
Caucasian	0.63 (0.50–0.78)	0.0082	0.41 (0.24–0.70)	0.0023	0.46 (0.37–0.58)	0.704	0.48 (0.39–0.59)	0.631	0.63 (0.38–1.06)	0.004
HBV infection versus NC
Overall	0.75 (0.68–0.82)	<0.001	0.57 (0.48–0.59)	0.001	0.65 (0.51–0.81)	<0.001	0.63 (0.52–0.76)	<0.001	0.74 (0.63–0.87)	<0.001
Asian	0.79 (0.72–0.87)	0.002	0.64 (0.53–0.77)	0.005	0.78 (0.69–0.90)	0.024	0.73 (0.64–0.85)	0.006	0.74 (0.64–0.85)	0.045
Caucasian	0.64 (0.56–0.73)	0.642	0.41 (0.31–0.54)	0.671	0.41 (0.18–0.90)	<0.001	0.41 (0.26–0.65)	0.015	0.72 (0.38–1.38)	<0.001
rs7453920	A versus G		AA versus GG		AG versus GG		AA + AG versus GG		AA versus AG + GG
	OR (95% CI)		OR (95% CI)		OR (95% CI)		OR (95% CI)		OR (95% CI)
HBV infection versus control
Overall	0.66 (0.52–0.84)	<0.001	0.50 (0.29–0.85)	<0.001	0.63 (0.52–0.77)	0.001	0.62 (0.50–0.78)	0.111	0.57 (0.35–0.92)	0.001
Asian	0.57 (0.49–0.65)	0.156	0.35 (0.23–0.53)	0.617	0.57 (0.48–0.67)	0.107	0.55 (0.46–0.64)	0.020	0.40 (0.26–0.60)	0.659
Caucasian	0.83 (0.58–1.19)	0.006	0.88 (0.51–1.52)	0.098	0.77 (0.55–1.08)	0.074	0.78 (0.52–1.15)	<0.001	1.01 (0.68–1.51)	0.218
HBV infection versus NC
Overall	0.61 (0.51–0.72)	<0.001	0.48 (0.29–0.78)	<0.001	0.58 (0.51–0.65)	0.006	0.57 (0.50–0.66)	<0.001	0.54 (0.34–0.86)	<0.001
Asian	0.55 (0.51–0.60)	0.570	0.36 (0.26–0.50)	0.419	0.55 (0.50–0.60)	0.323	0.53 (0.49–0.58)	0.521	0.41 (0.29–0.57)	0.401
Caucasian	0.80 (0.67–1.35)	<0.001	0.83 (0.33–2.08)	0.002	0.70 (0.45–1.08)	0.012	0.72 (0.42–1.24)	<0.001	0.96 (0.44–2.07)	0.007

NC: natural clearance; : value of heterogeneity test.