Downregulation of Profilin-1 Expression Attenuates Cardiomyocytes Hypertrophy and Apoptosis Induced by Advanced Glycation End Products in H9c2 Cells

Figure 4

Effect of different inhibitors on intracellular ROS generation and RhoA/ROCK signaling pathway mediated by AGEs in H9c2 cells. (a) Representative images show different inhibitors on intracellular ROS generation induced by AGEs (200 μg/ml, 24 hours). Rosup (50 μg/ml) was used as a positive control (magnification: 20x; scale bar: 100 μm). (b) Effect of different inhibitors on the protein expression of ROCK1, ROCK2, RAGE, and RhoA induced by AGEs. Data were expressed as mean ± SD, . versus control; versus AGEs (200 μg/ml, 24 hours).

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