Local Anesthetics, Procaine, Lidocaine, and Mepivacaine Show Vasodilatation but No Type 1 Allergy: A Double-Blind, Placebo-Controlled Study

Table 5

Multilevel analysis of estimated effects of covariates, on wheal diameter (dependent covariate). Linear trend (substance): influence of the respective LA on the slope of the time-dependent diameter curve. Quadratic trend (substance): influence of the respective LA on the square shape of the curve. BMI: body mass index. SE: standard error.

		SE		95% confidence interval
				Lower bound	Upper bound
Intercept	2.50	1.07	0.021	0.38	4.62
linear trend (all substances)	0.45	0.17	0.006	0.13	0.79
Quadratic trend (all substances)	−0.04	0.01	0.002	−0.06	−0.01
Procaine	0.01	0.07	0.878	−0.14	0.16
Lidocaine	0.21	0.91	0.815	−1.59	2.01
Mepivacaine	0.00	0.02	0.85	−0.05	0.04
BMI	1.04	0.77	0.18	−0.48	2.55
Gender	0.58	0.82	0.476	−1.02	2.19
Age	0.26	0.83	0.756	−1.37	1.88
Linear trend (procaine)	0.66	0.19	0.001	0.27	1.04
Linear trend (lidocaine)	0.04	0.21	0.841	−0.36	0.44
Linear trend (mepivacaine)	0,75	0,22	0,001	0,32	1,18
Quadratic trend (procaine)	−0,03	0,01	0,02	−0,06	−0,01
Quadratic trend (lidocaine)	0,00	0,01	0,859	−0,03	0,01
Quadratic trend (mepivacaine)	−0,04	0,02	0,015	−0,07	−0,01