Rapamycin and FTY720 Alleviate Atherosclerosis by Cross Talk of Macrophage Polarization and Autophagy

Figure 4

S1PR involvement in FTY720- and rapamycin-regulated foam cells; (a) real-time PCR analysis shown for S1pr1-5 expression in foam cells; (b) western blot showing apoptosis marker cleaved-CASPASE 3 and total CASPASE 3; (c) data representative of cleaved-CASPASE 3 levels relative to total CASPASE 3 levels shown as histograms. P < .05 vs. untreated controls. Results shown are representative of 3 independent experiments; each experiment was repeated 3 times.