The Influence of Formulation and Excipients on Propranolol Skin Permeation and Retention

Figure 3

Percentage of propranolol recovered in the skin (epidermis plus dermis) after 4 h of contact. White bars refer to intact skin; grey bars to stripped skin. Mean values±sd. Statistical differences with cream1: p<0.05; p<0.01. The difference between intact and stripped skin was significant for ointment1 (p<0.01) and for the gel (p<0.05).