Infant Skin Barrier, Structure, and Enzymatic Activity Differ from Those of Adult in an East Asian Cohort

Table 1

Inclusion and exclusion criteria for study enrollment.

A. Inclusion Criteria
1. Healthy, male or female infants aged 3 – 24 months and their mothers.
2. The mother subject must be 25-46 years of age and must be willing to present proof of guardianship.
3. For both groups mother and child must be generally in good health as determined from a medical history. Both mother and baby should be without any family history of atopic dermatitis.
4. The participating mother is the one who regularly cares for the child. The mother must be willing and able to follow all study directions, accept skin examination during the study.
5. The mother must agree for her child and herself not to participate in another study during this study.
B. Exclusion criteria
1. Subjects with known allergy, particularly to adhesive tapes or latex.
2. Subjects with excessively dry, red, or irritated skin on any part of the body.
3. Subjects with obvious skin conditions on any part of the body that could interfere with the outcome of the study, including psoriasis, eczema, rashes, broken skin, sunburn, hyperhidrosis etc.
4. Subjects who have fever or a known viral or bacterial infection at the beginning of the study.
5. Mother subjects pregnant at the beginning of study.
6. Subjects participating in any other clinical study.