Cisplatin-Induced Rodent Model of Kidney Injury: Characteristics and Challenges

Table 6

The acute lethal dose of cisplatin varies among strains of mice and rats.

Strain (origin),	LD100	End	Ref.
sex, age
BALB/c (Harlan)	14.5 mg/kg; ip	D7	[109, 120]
female, N=8
C57BL/6, Japan	15 mg/kg; ip	D10	[41]
Male, 11-15wk; N=5-6
CBA; female,	16 mg/kg; ip	D7	[149]
24 months, N=3-7
Wistar rats,	8 mg/kg; ip	D11	[110]
Male, N=17
	LD90
B6D2F1	14 mg/kg; ip	D8	[106]
Male, N=10
DBA2	16 mg/kg; ip	D10	[112]
Female; N=10
Swiss Webster	19.5 ± 0.8; iv	D10	[106]
Male, N=10
	LD50
DBA2	10.7 mg/kg; ip	D10	[112]
Female; N=10	(9.6-11.9mg/kg)
Swiss Webster	16.0 ± 0.8; iv	D10	[106]
Male, N=10
NMRI	17.0 mg/kg; ip	D10	[112]
Female; N=10	(14.9-19.7mg/kg)
Wistar rats	10.8 mg/kg; ip	D10	[112]
Female; N=10	(9.1-12.8 mg/kg)
Fischer 344 rats	11 mg/kg; ip	D6	[133, 152]
female, 8wks

N: number; ip: intraperitoneally; iv: intravenously; sc: subcutaneously; D: day; LD: lethal dose; LD100: dose of cisplatin that results in 100% mortality; LD50: dose of cisplatin that results in 50% mortality.