Protein Arginine Methyltransferase 2 Inhibits Angiotensin II-Induced Proliferation and Inflammation in Vascular Smooth Muscle Cells

Figure 1

Ang II induced VSMCs proliferation in a time-dependent and dose-dependent manner. (a-b) Dosage curve of cell proliferation when cells were treated with different concentrations of Ang II for 24 hours. (a) Cell viability; (b) PCNA protein level; P<0.05 versus 0 nM. (c-d) Time curve of VSMCs proliferation when cells were treated with 100 nM Ang II. (c) Cell viability; (d) PCNA protein level; P<0.05 versus 0 h. Ang II represents angiotensin II; VSMCs represent vascular smooth muscle cells; n=3 independent experiments.