Gallic Acid Attenuates Dimethylnitrosamine-Induced Liver Fibrosis by Alteration of Smad Phosphoisoform Signaling in Rats

Figure 4

Effects of GA on the liver histological structure of rats with DMN-induced liver fibrosis (hematoxylin–eosin staining, 200×), n = 8 animals/group, scale bar: 50 μm. The treatments were as follows: (a) control group, (b) DMN (3 mg/kg; 7 mg/kg), (c) DMN + silymarin (100 mg/kg), (d) DMN + GA (25 mg/kg), (e) DMN + GA (50 mg/kg), and (f) DMN + GA (100 mg/kg). Hyperplastic wire mesh-like collagen fibers around the liver cells (black circle), inflammatory cell infiltration (white arrow), and congestion in ECM (black arrow) were found in the DMN group.

(a)

(b)

(c)

(d)

(e)

(f)