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BioMed Research International
Volume 2018, Article ID 1925619, 11 pages
Research Article

Blood Groups Distribution and Gene Diversity of the ABO and Rh (D) Loci in the Mexican Population

1CIASaP, School of Medicine, Autonomous University of Sinaloa, 80246 Culiacan, SIN, Mexico
2The Women’s Hospital, Secretariat of Health, 80127 Culiacan, SIN, Mexico
3Innovation and Research Division, Salud Digna para Todos, 80000 Culiacan, SIN, Mexico
4Medical Division, Salud Digna para Todos, 80000 Culiacan, SIN, Mexico
5Clinical Laboratory Division, Salud Digna para Todos, 80000 Culiacan, SIN, Mexico
6Pediatric Hospital of Sinaloa, 80200 Culiacan, SIN, Mexico

Correspondence should be addressed to Jonathan Alcántar-Fernández; gro.angid-dulas@ratnacla.nahtanoj

Received 13 October 2017; Accepted 5 March 2018; Published 23 April 2018

Academic Editor: Maria C. De Rosa

Copyright © 2018 Adrián Canizalez-Román et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. To determine the frequency and distribution of ABO and Rh (D) antigens and, additionally, investigate gene diversity and the structure of Mexican populations. Materials and Methods. Blood groups were tested in 271,164 subjects from 2014 to 2016. The ABO blood group was determined by agglutination using the antibodies anti-A, Anti-B, and Anti-D for the Rh factor, respectively. Results. The overall distribution of ABO and Rh (D) groups in the population studied was as follows: O: 61.82%; A: 27.44%; B: 8.93%; and AB: 1.81%. For the Rh group, 95.58% of people were Rh (D), and 4.42% were Rh (d). Different distributions of blood groups across regions were found; additionally, genetic analysis revealed that the and allele showed an increasing trend from the north to the center, while the and allele tended to increase from the center to the north. Also, we found more gene diversity in both loci in the north compared with the center, suggesting population structure in Mexico. Conclusion. This work could help health institutions to identify where they can obtain blood products necessary for medical interventions. Moreover, this piece of information contributes to the knowledge of the genetic structure of the Mexican populations which could have significant implications in different fields of biomedicine.