Programmed Cell Death-1/Programmed Death-Ligand 1 Blockade Improves Survival of Animals with Sepsis: A Systematic Review and Meta-Analysis

Table 1

Characteristics of the included studies.

Paper/author	Animal/sex	Drug	Country	Administration; time	Dose	Age	Year	Control; group
Brahmamdam et al.	Mice/male	Anti-PD-1	USA	24-48h; after CLP	200ug in 200mL saline	8-10w	2010	(1)isotype
								(2)saline
Zhang et al.	Mice/male	Anti-PD-L1	CHINA	(a) 24h before; CLP	50 μg/mouse	8-10w-	2010	(3)isotype
								(4)saline
				(b) 3h after CLP				(5)isotype
								(6)saline
Chang et al.	Mice/male	(a) Anti-PD-1	USA	24-48h; after CLP	200ug-	8-10w	2015	(7)isotype
		(b) Anti-PD-L1					2015	(8)isotype
Shindo et al.	Mice/male	Anti-PD-L1	USA	48h after CLP	- -	6-8w	2017	(9)inactive