Review Article
Programmed Cell Death-1/Programmed Death-Ligand 1 Blockade Improves Survival of Animals with Sepsis: A Systematic Review and Meta-Analysis
Table 3
Subgroup results of PD-1 related blockade on survival in animals with sepsis.
| Subgroup
basis | Group
type | Included
studies (n) | p-value | RR (95%CI) | I2 | Subgroup
difference |
| | Dose | 200 ug | 4 | 0.94 | 1.97 (1.51-2.56) | 0 | P=0.14 | | 50 ug | 4 | 0.43 | 3.26 (1.75-6.08) | 0 | | Drug | Anti-PD-1 | 3 | 0.83 | 2.02 (1.43-2.82) | 0 | P=0.56 | | Anti-PD-L1 | 6 | 0.54 | 2.31 (1.70-3.14) | 0 | | Administration time | <48h | 8 | 0.73 | 2.23 (1.74-2.81) | 0 | P=0.69 | | >48h | 1 | 0.03 | 1.96 (1.08-3.54) | 0 |
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