In Vitro Cytotoxicity and In Vivo Antimammary Tumor Effects of the Hydroethanolic Extract of Acacia seyal (Mimosaceae) Stem Bark

Figure 3

Effects of A. seyal extract on microphotographs H&E 400× of mammary glands (A), uterine (B), and vagina (C) and graphic representations of uterine (D) and vagina (E) height after 20 weeks of treatment. NOR = normal control treated with water; DMBA = DMBA control treated with water; AS + DMBA = animals treated with the A. seyal hydroethanolic aqueous extract at the doses of 50, 150, and 300 mg/kg. TAM + DMBA = animals treated with tamoxifen (3.3 mg/kg); all groups except the normal group (NOR) received an intragastric dose of DMBA at the dose of 80 mg/kg. Data are represented as mean ± SEM (). Data are represented as mean ± SEM (). Data are represented as mean ± SEM (). , as compared to negative control. La = lumen of alveoli; At = adipose tissue; Se = eosinophil secretion; L = lobular; HLU = hyperplastic lobular unit; St = stroma; En = endometrium; Lu = lumen of uterine; Ge = germinal epithelium.

(a)

(b)

(c)

(d)

(e)