Research Article

In Vitro Cytotoxicity and In Vivo Antimammary Tumor Effects of the Hydroethanolic Extract of Acacia seyal (Mimosaceae) Stem Bark

Table 3

Breast cancer chemopreventive activity of A. seyal extract after 20 weeks of treatment.

ItemsNORDMBATamox + DMBAAS 50 + DMBAAS 150 + DMBAAS 300 + DMBA

Number of rats with tumors/total rats0/1211/123/127/125/123/12
Tumor incidence (%)0
Average tumor weight (g/kg)-
% inhibition related to tumor weight--82.943.762.165.8
Total tumor burden (g)05.510.973.22.161.78
% Inhibition related to tumor burden--82.3941.9260.7967.69

NOR = normal control treated with 2% ethanol; DMBA = DMBA control treated with 2% ethanol; AS + DMBA = animals treated with the Acacia seyal hydroethanolic extract at the doses of 50 and 200 mg/kg. TAM + DMBA = animals treated with tamoxifen (3.3 mg/kg); all groups excepting the normal group (NOR) received an intragastric dose of DMBA at the dose of 80 mg/kg. Data are represented as mean ± SEM (). and as compared to negative control; as compared to normal control.