In Vitro Cytotoxicity and In Vivo Antimammary Tumor Effects of the Hydroethanolic Extract of Acacia seyal (Mimosaceae) Stem Bark

Table 6

Effects of A. seyal hydroethanolic extract on hematological parameters after 20 weeks of treatment.

Items	NOR	DMBA	Tamox + DMBA	AS 50 + DMBA	AS 150 + DMBA	AS 300 + DMBA
WBC (×10^3µL^−1)	3,3 ± 0,2	6,04 ± 0,4	3,5 ± 0,4	6,9 ± 0,52	4,32 ± 0,46	4,46 ± 0,71
Lymphocytes (%)	63,74 ± 1,50	61,6 ± 1,17	61,8 ± 1,17	67,66 ± 0,71	62,08 ± 2,51	63,66 ± 0,68
Monocytes (%)	14,62 ± 0,52	16,8 ± 0,75	19,21 ± 0,61	12 ± 0,6	15,56 ± 1,84	11,33 ± 0,5
Granulocytes (%)	21,64 ± 1,06	21,6 ± 1,13	18,78 ± 1,21	20,33 ± 0,25	22,36 ± 0,84	25 ± 0,22
RBC (×10^3 µL^−1)	7,66 ± 0,21	7,22 ± 0,11	6,81 ± 0,5	6,88 ± 0,18	7,13 ± 0,08	5,14 ± 0,5
Hematocrit (%)	48,46 ± 1,20	45,76 ± 1,02	45,51 ± 2,31	43,96 ± 1,31	44,5 ± 0,8	30,1 ± 2,9
MCV (fL)	63,86 ± 0,31	63,34 ± 0,67	64,85 ± 2,37	63,9 ± 0,26	62,5 ± 0,64	58,83 ± 0,2
Platelets (×10^3 µL^−1)	479,6 ± 47,87	435,2 ± 23,21	237,5 ± 36,4	383 ± 54,14	478 ± 17,32	259,66 ± 24,6
MCH (pg)	18 ± 0,14	18,04 ± 0,16	18,83 ± 1,10	17,6 ± 0,12	17,9 ± 0,17	17,13 ± 0,12
Hemoglobin (g/dL)	137 ± 3,13	129,2 ± 2,04	131,33 ± 4,77	121,66 ± 4,00	128,2 ± 1,90	88,33 ± 8,8
MCHC (g/dL)	282,4 ± 1,38	282,4 ± 2,77	290 ± 5,63	275,66 ± 1,64	287,4 ± 1,62	291,66 ± 1,12

NOR = normal control treated with water; DMBA = DMBA control treated with water; AS + DMBA = animals treated with the A. seyal hydroethanolic aqueous extract at the doses of 50, 150 and 300 mg/kg. TAM + DMBA = animals treated with tamoxifen (3.3 mg/kg); all groups excepting the normal group (NOR) received an intragastric dose of DMBA at the dose of 80 mg/kg. Data are represented as mean ± SEM (). and as compared to negative control; as compared to normal control. as compared to the negative control; as compared to normal control.