Hydrogen Sulfide Protects against Chemical Hypoxia-Induced Injury via Attenuation of ROS-Mediated Ca²⁺ Overload and Mitochondrial Dysfunction in Human Bronchial Epithelial Cells

Figure 1

The effects of CoCl₂ and H₂S on the viability of 16HBE14o- cells were determined by CCK-8. (a) The viability of 16HBE14o- cells preconditioned with a series of CoCl₂ concentration (0, 100, 200, 400, 600, or 1000 μmol/L). (b) The viability of 16HBE14o- cells treated with 400 μmol/L CoCl₂ and NaHS in varying doses (0, 100, 200, 400, 600, or 1000 μmol/L) (mean± SD, n=4, p < 0.05, p < 0.01, p < 0.001 versus control group, #p < 0.05, ###p < 0.001 versus hypoxia group).

(a)

(b)