lncRNA-MEG3 Suppresses the Proliferation and Invasion of Melanoma by Regulating CYLD Expression Mediated by Sponging miR-499-5p

<div>The effect of MEG3 on A375 cell proliferation and cell cycle. (a) Upregulation of MEG3 effectively blocked cell cycle at the G0/G1 stage. (b) Downregulation of MEG3 heavily promoted cell cycle. (c) The transfection of pcDNA-meg3 attenuated the proliferation of A375 cells. (d) The growth of A375 cells was enhanced significantly in sh-MEG3 group. (e) The MEG3 level was increased in pcDNA-MEG3 group. (f) The expression of MEG3 was decreased in sh-MEG3 group. 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BioMed Research International

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Figure 3

Figure 3: lncRNA-MEG3 Suppresses the Proliferation and Invasion of Melanoma by Regulating CYLD Expression Mediated by Sponging miR-499-5p 