Research Article

Incidence of Hippocampal Metastases: Laterality and Implications for Unilateral Hippocampal Avoiding Whole Brain Radiotherapy

Table 3

Presence of brain metastases (or their centre) within right and left hippocampus and hippocampal avoiding zones and laterality of hippocampal involvement.

withinwithinwithinP valuewithinwithinwithinP value
Hleft Hright HHAZleft HAZright HAZ

Patients (n=260) with edge of MTS20 (7.7%)12 (4.6%)12 (4.6%)47
(18.1%)
30 (11.5%)27
(10.4%)
Patients (n=260) with more MTS89NS2220p = 0.88
Patients (n=260) with centre of MTS5 (1.9%)3
(1.2%)
3
(1.2%)
25
(9.6%)
19
(7.3%)
12
(4.6%)
Patients (n=260) with more centre of MTS22NS156p = 0.07
Number of MTS (n=2595) with edge28 (1.1%)12 (0.5%)16 (0.6%)p = 0.5786
(3.3%)
42
(1.6%)
44
(1.7%)
p = 0.91
Number of MTS (n=2595) with centre of MTS7 (0.3%)3
(0.1%)
4
(0.1%)
NS41
(1.6%)
25
(0.9%)
16
(0.6%)
p = 0.21

MTS: metastasis, H: hippocampus, HAZ: hippocampus avoiding zone, NS: not specified, and p value close to 1.