Decreased Endometrial IL-10 Impairs Endometrial Receptivity by Downregulating HOXA10 Expression in Women with Adenomyosis

Figure 4

Impaired phosphorylation of STAT3 in endometria from women with adenomyosis. Timed midsecretory endometrial biopsies from normal control women (n=20) and women with adenomyosis (n=20) were analyzed for STAT3 and p-STAT3 expression via western blotting (a), and the expression levels of STAT3 (b) and p-STAT3 (c) were compared between the two groups. The correlation between IL-10 and STAT3 protein levels was analyzed in all of the women (n=40) (d). Representative images of STAT3 and p-STAT3 staining in the endometria of women with adenomyosis and normal controls are shown (e). The integrated optical density (IOD) levels of STAT3 (f) and p-STAT3 (g) were compared between the two groups (n=3). The data are plotted as the mean ± SEM. P<0.05; P<0.01; P<0.001.

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