Research Article

A Bioinformatic Profile of Gene Expression of Colorectal Carcinoma Derived Organoids

Table 4

Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis of differentially expressed genes (DEGs) in tumor organoids.

CategoryKEGG pathwayGenes Count%P-ValueGene members

UpregulatedWnt signaling pathway553.20E-03NM_012342, NM_004655, NM_014420, NM_001166119, NM_033119
Basal cell carcinoma332.50E-02NM_004655,NM_001166119, NM_001083602
Pathways in cancer662.90E-02NM_004655, NM_019851, NM_002010, NM_212482, NM_001166119, NM_001083602
Adherens junction334.00E-02NM_001166119, NM_005985, NM_001034954

DownregulatedRap1 signaling pathway931.40E-02NM_000899, NM_003253, NM_021116, NM_001992, NM_001962, NM_002006, NM_022970, NM_057159, NM_003246
Bladder cancer41.42.40E-02NM_000584, NM_004938, NM_002421, NM_003246
Pantothenate and CoA biosynthesis313.00E-02NM_006208, NM_005021, NM_004666
Pathways in cancer124.13.60E-02NM_000584, NM_000899, NM_004991, NM_021116, NM_001200, NM_001992, NM_004938, NM_002006, NM_022970, NM_057159, NM_002421, NM_000958
Regulation of actin cytoskeleton82.74.10E-02NM_006633, NM_003253, NM_001992, NM_002006, NM_022970, NM_001127663, NM_053025, NM_001112706
Renin-angiotensin system314.70E-02NM_001150, NM_021804, NM_000537