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BioMed Research International
Volume 2018, Article ID 2607679, 6 pages
Research Article

Effects of Melatonin on Intestinal Microbiota and Oxidative Stress in Colitis Mice

College of Bioscience and Biotechnology, College of Animal Science and Technology, Hunan Agricultural University, Changsha, Hunan 410128, China

Correspondence should be addressed to Hongmei Jiang; nc.ude.uanuh@ncdnmhj and Jun Fang; nc.ude.uanuh@3791nujgnaf

Received 14 October 2017; Revised 29 December 2017; Accepted 4 January 2018; Published 6 February 2018

Academic Editor: Lidong Zhai

Copyright © 2018 Dan Zhu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


This study investigated the antioxidant capacity and intestinal bacteria community in a mouse model of DSS-induced colitis. Twenty mice were randomly assigned to two treatments: mice with colitis induced by 5% DSS (DSS group) and mice with colitis induced by 5% DSS that also received melatonin treatment (MEL group). The DSS group showed significantly less antioxidant capability than the MEL group, but the two groups did not differ significantly in terms of diversity index (Shannon and Simpson), bacterial culture abundance (Chao1 and ACE), and coverage (Good’s coverage estimator). Bacteroidetes were the most abundant phylum in the DSS group (58.93%), followed by Firmicutes with 31.46% and Proteobacteria with 7.97%. In contrast, Firmicutes were the most abundant in the MEL group (49.48%), followed by Bacteroidetes with 41.63% and Proteobacteria with 7.50%. The results support the use of melatonin for prevention of intestinal bowel disease due to its modulatory effect on antioxidant capability and microbiota in mice with colitis. Melatonin was demonstrated to improve the oxidative stress resistance of mice with colitis and regulate the intestinal microbial flora, thus improving intestinal health.