Microarray-Based Detection and Clinical Evaluation for Helicobacter pylori Resistance to Clarithromycin or Levofloxacin and the Genotype of CYP2C19 in 1083 Patients

Table 7

Correlation between H. pylori mutations and CYP2C19 genetic polymorphism.

CYP2C19 polymorphism (cases)	Mutation rates (%) and cases (n)
	23S rRNA	gyrA N87K	gyrA D91G/ D91N
Hom-EMs (284)	27.82 (79)	19.01 (54)	6.34 (18)
Het-EMs (343)	30.90 (106)	21.57 (74)	9.91 (34)
PMs (64)	17.19 (11)	15.63 (10)	6.25 (4)
P value	0.079	0.479	0.224

Hom-EMs: homozygous extensive metabolizers; Het-EMs: heterozygous extensive metabolizers; PMs: poor metabolizers