Review Article

The Dental Management of Patients at Risk of Medication-Related Osteonecrosis of the Jaw: New Paradigm of Primary Prevention

Table 4

Drug suspension for cancer patients; it must be agreed upon with the oncologist and performed according to the table.

Drug holiday in cancer patients
Active pharmaceutical ingredientLast administrationResume treatment

Bisphosphonate (AR)At least 1 week before4–6 weeks after
Denosumab (AR)At least 1 week before4–6 weeks after
Bevacizumab (AA)At least 6-7 weeks before4–6 weeks after
Sunitinib (AA)At least 1 week before4–6 weeks after
Everolimus (AA)At least 1 week before4–6 weeks after