Neutrophil Lymphocyte Ratio and Cardiovascular Disease Risk: A Systematic Review and Meta-Analysis

Table 2

Pooled odds ratio of cardiovascular between high and low NLR.

Author	Year	NLR	CVD		Non-CVD		OR (95%CI)
		Cutoff	Low NLR	High NLR	Low NLR	High NLR
Coronary artery disease
Sari [13]	2015	2.30	-	-	-	-	1.51 (1.15, 2.00)
Aygün [14]	2015	2.05	40	56	109	87	1.75 (1.07, 2.88)
Acar [15]	2015	2.25	-	-	-	-	2.30 (1.19, 4.43)
Verdoia [16]	2015	2.03	349	783	103	137	1.69 (1.27, 2.24)
Yu [18]	2016	2.41	-	-	-	-	1.69 (1.48,1.94)
Verdoia [20]	2016	1.80	682	2172	251	633	1.26 (1.07, 1.49)
Chittawar [23]	2017	2.60	2	8	197	58	13.59 (2.81, 65.76)
Guo [24]	2017	2.45	-	-	-	-	2.01 (0.88, 4.63)
Sharma [25]	2017	2.13	-	-	-	-	1.49 (0.94, 2.37)
Pooled OR (95% CI)							1.62 (1.38, 1.91)
Acute coronary syndrome
Yu [18]	2016	2.42	-	-	-	-	1.65 (1.43, 1.90)
Zazula [27]	2008	5.70	-	-	-	-	4.51 (1.51, 13.45)
Nordestgaard [28]	2010	-	-	-	-	-	1.52 (0.83, 2.79)
Caimi [29]	2015	2.19	39	43	11	12	1.01 (0.40, 2.55)
Göktaş [32]	2018	3.0	40	23	26	11	1.36 (0.57, 3.25)
Pooled OR (95% CI)							1.64 (1.30-2.05)
Stroke
Saliba [33]	2015	3.15	649	332	24049	7882	1.56 (1.36, 1.79)
Ertas [34]	2013	3.17	20	19	64	23	2.64 (1.20, 5.81)
Akil [36]	2014	-	-	-	-	-	8.95 (1.88, 42.61)
Suh [39]	2017	3.00	23,530	219	936	23	2.64 (1.71, 4.08)
Pooled OR (95% CI)							2.36 (1.44, 3.89)
Composite outcomes
Tsai [43]	2007	-	-	-	-	-	1.52 (0.96, 2.40)
Azab [44]	2013	2.40	20	206	23	89	2.66 (1.39, 5.09)
Solak [45]	2013	2.80	3	63	109	50	45.78 (13.71, 152.85)
Abe [46]	2015	3.67	10	26	33	17	5.05 (1.98, 12.86)
Quiros-Roldan [47]	2016	1.20	22	90	1091	2251	1.98 (1.24, 3.18)
Pooled OR (95% CI)							3.86 (1.73, 8.64)

CI, confidence interval; CVD, cardiovascular disease; NLR, neutrophil lymphocyte ratio; OR, odds ratio.